C Met Antibody Cell Signaling

The primary single chain precursor protein is post translationally cleaved to produce the alpha and beta subunits which are disulfide linked to form the mature receptor.

C met antibody cell signaling.

155 kda lanes 1 2. These fundamental events are important for all of the biological functions involving met kinase activity. Oncol rep 41 1497 1508 2019. The cells were labeled c met 3d4 mouse monoclonal antibody 187366 at 1 250 dilution in0 1 bsa and incubated for 3 hours at room temperature and then labeled with goat anti mouse igg h l superclonal secondary antibody alexa fluor 488 conjugate product a28175 at a dilution of 1 2000 for 45 minutes at room temperature panel a.

C met also called tyrosine protein kinase met or hepatocyte growth factor receptor hgfr is a protein that in humans is encoded by the met gene the protein possesses tyrosine kinase activity. Red loading control ab18058 observed at 130 kda. Du m et al. In order to learn how oncogene addiction can be broken in tumors with met amplification by the anti c met monoclonal antibody abt 700 cell signaling technology c met antibody cell signaling 3077 was used in immunohistochemistry paraffin section on human samples fig 3 and in western blot on human samples fig 1.

Zero bias scores article reviews protocol conditions and more. Interaction of met with hgf results in autophosphorylation at multiple tyrosines which recruit several downstream signaling components including gab1 c cbl and pi3 kinase 3. Wild type hap1 whole cell lysate lane 2. Ab74217 has been referenced in 9 publications.

Anti met c met antibody epr19067 ab216574 at 1 1000 dilution lane 1. Ligand binding at the cell surface induces autophosphorylation of met that provides docking sites for downstream signaling molecules. Anti c met supplied by cell signaling technology inc used in various techniques. Yin l et al.

These fundamental events are important for all of the biological functions involving met kinase activity. Microrna 200a suppresses migration and invasion and enhances the radiosensitivity of nsclc cells by inhibiting the hgf c met signaling pathway. Interaction of met with hgf results in autophosphorylation at multiple tyrosines which recruit several downstream signaling components including gab1 c cbl and pi3 kinase 3. Merged signal red and green.

These fundamental events are important for all of the biological functions involving met kinase activity. It is linked to functions such as cell proliferation scattering morphogenesis and survival. Met is a tyrosine kinase receptor for the hepatocyte growth factor. Interaction of met with hgf results in autophosphorylation at multiple tyrosines which recruit several downstream signaling components including gab1 c cbl and pi3 kinase 3.

99 100 based on 5 pubmed citations.